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publications.

Over the years, we have contributed to a range of academic publications advancing the field of (ultrasound) drug delivery. Explore our research and discover the impact of our work in collaboration with leading experts and institutions.

     selection of relevant
     publications.

  • Poon C, Mühlenpfordt M, Olsman M, Kotopoulis S, de Lange Davies C, Hynynen K. Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability. J. Vis. Exp. (180), e62235, doi:10.3791/62235 (2022). https://dx.doi.org/10.3791/62235-v
     
  • Olsman M, Sereti V, Mühlenpfordt M, Johnsen C, Andresen T, Urquhart A, de Lange Davies C. Focused ultrasound and microbubble treatment increases delivery of transferrin receptor-targeting liposomes in the brain. Ultrasound in Medicine & Biology 2021 47 (5), 1343-1355. https://doi.org/10.1016/j.ultrasmedbio.2021.01.014
     
  • Olsman M, Ultrasound and microbubble treatment for improved delivery of nanomedicine to tumours and the brain. PhD thesis 2021. https://hdl.handle.net/11250/2739276.
     
  • Tibbe M, Improving Organ on‐Chip Physiology: Exploring the barrier in blood‐brain barrier on‐chip systems. PhD thesis 2020. https://research.utwente.nl/files/171415634/PhD_Thesis_Martijn_Tibbe.pdf.
     
  • Helbert A, Gaud E, Segers T, Botteron C, Frinking P, Jeannot V. Monodisperse versus Polydisperse Ultrasound Contrast Agents: In Vivo Sensitivity and safety in Rat and Pig. https://doi.org/10.1016/j.ultrasmedbio.2020.07.031
     
  • Segers T, Gaud E, Casqueiro G, Lassus A, Versluis M, Frinking P. Foam-free monodisperse lipid-coated ultrasound contrast agent synthesis by flow-focusing through multi-gas-component microbubble stabilization. https://doi.org/10.1063/5.0003722
     
  • Segers T, Lassus A, Bussat P, Gaud E, Frinking P. Improved coalescence stability of monodisperse phospholipid-coated microbubbles formed by flow-focusing at elevated temperatures. https://pubmed.ncbi.nlm.nih.gov/30511070/
     
  • Segers T, Lohse D, Versluis M, Frinking P. Universal equations for the coalescence probability and long-term size stability of phospholipid-coated monodisperse microbubbles formed by flow focusing. https://doi.org/10.1021/acs.langmuir.7b02547

    scientific presentations.

  • Monodisperse microbubbles for drug delivery across the blood brain barrier. Presented at the 30th European Symposium on Ultrasound Contrast Imaging, 2025.
  • Focused ultrasound-mediated drug delivery across the blood-brain barrier in mice using monodisperse microbubbles. Presented at the 24th Annual International Symposium for Therapeutic Ultrasound, 2025.
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